If used for long term.... such as 5 yrs... *Link*

One of the most serious side effects is a toxicity in the eye (generally with chronic use).[15]� People taking 400� mg of hydroxychloroquine or less per day generally have a negligible risk of� macular� toxicity, whereas the risk begins to go up when a person takes the medication over 5 years or has a cumulative dose of more than 1000� grams

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